PTD-DBM
Follicle Neogenesis Peptide
The only peptide shown to grow entirely new follicles
Overview
PTD-DBM inhibits CXXC-type zinc finger protein 5 (CXXC5), a negative regulator of the Wnt pathway in hair follicles. Korean researchers demonstrated that blocking CXXC5 led to de novo hair follicle neogenesis — growing new follicles in areas that previously had none. This is fundamentally different from reactivating dormant follicles.
Mechanism of Action
Competes with CXXC5 for dishevelled (Dvl) binding, freeing the Wnt/β-catenin cascade from inhibition. Combined with valproic acid (which also inhibits CXXC5), showed ~80% follicle recovery in animal models.
CXXC5 inhibition → Wnt derepression
Key Benefits
Protocol
Dose
1–2 mg
Frequency
Every other day
Duration
16–24 weeks
Method
Topical with penetration enhancer or microneedling
Research Evidence
Published Studies
12+
Key Finding
De novo follicle formation demonstrated in vivo
Source PTD-DBM
$55
per vial · research grade
Shop PTD-DBM≥98% purity · COA available · Research use only
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